Search ADS. Vascular remodelling in the pathogenesis of idiopathic pulmonary fibrosis.
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Prevalence of gastroesophageal reflux in end-stage lung disease candidates for lung transplant. Improved lung allograft function after fundoplication in patients with gastroesophageal reflux disease undergoing lung transplantation. Sole treatment of acid gastroesophageal reflux in idiopathic pulmonary fibrosis: a case series.
Comorbid occurrence of laryngeal or pulmonary disease with esophagitis in United States military veterans. Role of diabetes mellitus and gastro-oesophageal reflux in the aetiology of idiopathic pulmonary fibrosis. Gastro-oesophageal reflux and gastric aspiration in idiopathic pulmonary fibrosis patients. Idiopathic pulmonary fibrosis and gastroesophageal reflux. Implications for treatment. Gastroesophageal reflux disease and patterns of reflux in patients with idiopathic pulmonary fibrosis using hypopharyngeal multichannel intraluminal impedance.
Gastro-oesophageal reflux and aspiration in patients with advanced lung disease. High prevalence of abnormal acid gastro-oesophageal reflux in idiopathic pulmonary fibrosis. Increased prevalence of gastroesophageal reflux in patients with idiopathic pulmonary fibrosis. Prevalence of hiatal hernia by blinded multidetector CT in patients with idiopathic pulmonary fibrosis.
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Gastroesophageal reflux in patients with idiopathic pulmonary fibrosis referred for lung transplantation. Characterization of the innate immune response to chronic aspiration in a novel rodent model. Exposure of airway epithelium to bile acids associated with gastroesophageal reflux symptoms: a relation to transforming growth factor-beta1 production and fibroblast proliferation.
Gastric juice from patients "on" acid suppressive therapy can still provoke a significant inflammatory reaction by human bronchial epithelial cells. Clinical course and prediction of survival in idiopathic pulmonary fibrosis.
Pepsin in bronchoalveolar lavage fluid: a specific and sensitive method of diagnosing gastro-oesophageal reflux-related pulmonary aspiration. Bronchoalveolar pepsin, bile acids, oxidation, and inflammation in children with gastroesophageal reflux disease. Bronchoalveolar lavage pepsin in acute exacerbation of idiopathic pulmonary fibrosis. Progression of idiopathic pulmonary fibrosis: lessons from asymmetrical disease.
Laparoscopic fundoplication in patients with end-stage lung disease awaiting transplantation. Gastroesophageal reflux therapy is associated with longer survival in patients with idiopathic pulmonary fibrosis. Anti-acid treatment and disease progression in idiopathic pulmonary fibrosis: an analysis of data from three randomised controlled trials.
Association between dinner-to-bed time and gastro-esophageal reflux disease. Nocturnal reflux episodes following the administration of a standardized meal. Does timing matter? All rights reserved. For Permissions, please email: journals. Issue Section:. Download all figures. View Metrics. Email alerts New issue alert. Advance article alerts. Article activity alert. Receive exclusive offers and updates from Oxford Academic. More on this topic How we will diagnose IPF in the future. Chronic Obstructive Pulmonary Disease COPD is a chronic illness with a long clinical course characterised by episodes of worsening respiratory signs and symptoms due to acute exacerbations leading to increased usage of health care resources and much disability in later part of the life.
Gastroesophageal reflux disease GERD is a common problem of the general population and has been seen by many researchers throughout the world as a potential risk factor for exacerbations in COPD due to micro aspiration of the gastric contents. This may be due to gastroesophageal dysfunction, leading to decreased tone and pressure in the lower oesophageal sphincter and oesophageal dysmotility. Many medications used by patients with COPD or changes in respiratory mechanics with increased lung hyperinflation may lead to this gastroesophageal dysfunction.
GERD is amenable to treatment by both medical and surgical methods. This should help in reducing the exacerbations and improving the quality of life in patients with COPD. Hence further studies are needed to understand the cause-effect relationship. This case highlights the need to consider gastroesophageal reflux as a cause of nutritional failure despite enteral feeding and laparoscopic fundoplication as a therapy despite poor lung function.
Written consent to publication has been obtained from the patient.
Anti-Reflux Surgery Slows Idiopathic Lung Fibrosis | MedPage Today
Email: ku. Introduction Gastro-oesophageal reflux is common in children and adults with cystic fibrosis CF. Case report At transfer at the age of 16 years she weighed Open in a separate window. Figure 1. Figure 2. Figure 3. Preoperative CT demonstrating severe bilateral bronchiectasis with sputum plugging. Discussion This case raises a number of points for discussion.
Impact of reflux on cystic fibrosis lung disease Gastro-oesophageal reflux is caused by inappropriate relaxation of the lower oesophageal sphincter. Figure 4. Nutritional management Throughout her childhood nutritional status was always a concern, her BMI was well below the 4th centile.
Reflux and lung transplantation GOR is a relative contraindication to lung transplantation. MDT decision about high-risk surgery Others have described their approaches to decision-making in high-risk situations. Conclusions This case highlights the importance of the MDT approach to management of malnutrition, assessment for high-risk surgery and perioperative management. Ethical approval Written consent to publication has been obtained from the patient.
Contributorship All authors contributed equally. Acknowledgements The authors wish to thank the multidisciplinary team at the Royal Brompton Hospital. References 1. Characteristics of gastroesophageal reflux and potential risk of gastric content aspiration in children with cystic fibrosis. Gastro-oesophageal reflux and aspiration of gastric contents in adult patients with cystic fibrosis. Gut ; 57 —55 [ PubMed ]. Factors associated with poor pulmonary function: cross-sectional analysis of data from the European epidemiological registry of cystic fibrosis.
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Respiratory Complications of Gastroesophageal Reflux
Malnutrition in adults with cystic fibrosis. J Pediatr Surg ; 42 —4 [ PubMed ]. Mechanisms of gastroesophageal reflux in ambulant healthy human subjects. Gastroenterology ; —91 [ PubMed ]. Gastroesophageal reflux in bronchiolitis obliterans syndrome: A new perspective. Characteristics of gastroesophageal reflux in adults with cystic fibrosis. J Cyst Fibros ; 9 —70 [ PubMed ]. Gastric acid inhibition for fat malabsorption or gastroesophageal reflux disease in cystic fibrosis: Longitudinal effect on bacterial colonization and pulmonary function. J Pediatr ; —8 [ PubMed ].
International guidelines for the selection of lung transplant candidates: update. A consensus report from the pulmonary scientific council of the international society for heart and lung transplantation.